Patient-Reported Outcomes Offer Insight to Adherence Barriers

Measuring non-adherence using patient reported outcomes (PRO)

Patient-Reported Outcomes Offer Insight to Adherence Barriers

With oral antineoplastic agents (OAAs) becoming the mainstay of treatment for several cancer types, understanding risk factors for medication non-adherence is becoming increasingly important in oncology. Patient-reported outcome (PRO) instruments may provide valuable insight on barriers to medication adherence in the real world. “Measuring risk factors for non-adherence using patient-reported outcomes in studies evaluating adherence with oral antineoplastic agents: A 10-year review,” a study presented at ISPOR in June, sought to identify and describe key patient-reported risk factors for non-adherence measured in observational studies evaluating adherence with OAAs.

A targeted literature review was conducted to identify OAA adherence studies utilizing PROs and published between January 2004 and December 2014. Key data abstracted from each retained article included:

  • Study design
  • Cancer type
  • PRO instruments or study-specific questionnaires used
  • Domains measured by each PRO instrument and questionnaire

Eleven studies were reviewed in detail. The most commonly used PRO instruments were the Beliefs about Medicines Questionnaire (BMQ; n=4) and the Satisfaction with Information about Medicines Scale (SIMS; n=3). Six studies (55%) used a validated PRO to measure health-related quality of life (HRQL); however, only the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) was used in more than one study.

Concluding, risk factors for non-adherence are commonly measured by patient-report in observational studies evaluating adherence with OAAs. Overall, quality of life, knowledge and satisfaction with information about medicine, perception of illness, beliefs about medicine, relationship/trust with treating physician, and side-effects were identified as predictors of non-adherence.

Contact us to discuss how our team of researchers can implement various study designs, including literature reviews, database analyses, chart reviews, surveys, and prospective studies to help you understand real world adherence rates and risk factors for non-adherence with your product

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