Study: Fatigue and Bone-Related Symptoms Most Impact the Health-Related Quality of Life of Patients with Multiple Myeloma

A UBC study assesses health-related quality of life of multiple myeloma patients

Study: Fatigue and Bone-Related Symptoms Most Impact the Health-Related Quality of Life of Patients with Multiple Myeloma

A study, designed and undertaken by medical and industry experts including Krista Payne and Noreen Lordan of UBC, assesses the health-related quality of life (HRQoL) of 154 patients with multiple myeloma (MM).  This cross-sectional, bi-national, multicenter study enrolled patients with MM presenting for routine care visits at five United Kingdom and six German sites.

This study is one of the first to assess the impact of general severity level of disease symptoms and treatment-related adverse events (AEs) on patients’ HRQoL.  The study also examines whether specific symptoms or AEs affect the HRQoL of patients with MM more than others.  The authors reported that severity, type of disease symptoms, and treatment-related AEs are important determinants of HRQoL in patients with MM.  Fatigue and bone-related symptoms (i.e., pain and fracture) emerged as the strongest predictors of HRQoL.  These findings underscore the need to prioritize the optimal management of these symptoms in this patient population. 

An article summarizing the study results can be found in the February 2014 issue of Supportive Care in Cancer.